› 4iul

X-ray diffraction
2.3Å resolution

MIF4G domain of DAP5

Released:
DOI: 10.2210/pdb4iul/pdb
PDB entry 4iul coloured by chain, front view.
PDB entry 4iul coloured by chain, side view.
PDB entry 4iul coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A.
Virgili G, Frank F, Feoktistova K, Sawicki M, Sonenberg N, Fraser CS, Nagar B
Structure 21 517-27 (2013)
PMID: 23478064

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-160246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4 gamma 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 268 amino acids
Theoretical weight: 30.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78344 (Residues: 61-323; Coverage: 29%)
Gene names: DAP5, EIF4G2, OK/SW-cl.75
Sequence domains: MIF4G domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 167.696Å b: 56.696Å c: 74.374Å
α: 90° β: 112.05° γ: 90°
R-values:
R R work R free
0.224 0.221 0.256
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Transcriptome-wide studies uncover the diversity of modes of mRNA recruitment to eukaryotic ribosomes.
Shatsky et al. (2014)
3 more

6 mentions without citation

The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation.
Friedrich et al. (2022)
5 more