› 4ivc

X-ray diffraction
2.35Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23458 (Residues: 854-1154; Coverage: 26%)
Gene names: JAK1, JAK1A, JAK1B
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1J6 2 x 1J6
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 42.329Å b: 172.868Å c: 44.124Å
α: 90° β: 94.75° γ: 90°
R-values:
R R work R free
0.2 0.197 0.263
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Selective JAK inhibitors in development for rheumatoid arthritis.
Norman P. (2014)
5 more

3 mentions without citation

Comparison of Data Fusion Methods as Consensus Scores for Ensemble Docking.
Bajusz et al. (2019)
2 more