› 4ixc

X-ray diffraction
2Å resolution

Crystal structure of Human Glucokinase in complex with a small molecule activator.

Released:
DOI: 10.2210/pdb4ixc/pdb
PDB entry 4ixc coloured by chain, front view.
PDB entry 4ixc coloured by chain, side view.
PDB entry 4ixc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ogg DJ, Hargreaves D, Gerhardt S

Function and Biology Details

Reaction catalysed: 
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152941 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-4 Chain: A
Molecule details ›
Chain: A
Length: 456 amino acids
Theoretical weight: 50.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 15-465; Coverage: 97%)
Gene name: GCK
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand GLC 1 x GLC
Ligand 1JD 1 x 1JD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: P41
Unit cell:
a: 77.628Å b: 77.628Å c: 85.824Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.186 0.249
Expression system: Escherichia coli

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