Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Source organism:
Mycobacterium tuberculosis
Biochemical function:
acyltransferase activity, transferring groups other than amino-acyl groups
Biological process: DIM/DIP cell wall layer assembly
Cellular component: polyketide synthase complex
Biological process: DIM/DIP cell wall layer assembly
Cellular component: polyketide synthase complex
Protein families (Pfam)![The deposited structure of PDB entry 4jaq contains 4 copies of Pfam domain PF02797 (Chalcone and stilbene synthases, C-terminal domain) in Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4jaq_1_A_Pfam_PF02797_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jaq</span> contains 4 copies of Pfam domain <span class='highlight'>PF02797 (Chalcone and stilbene synthases, C-terminal domain)</span> in <span class='highlight'>Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 4jaq contains 4 copies of Pfam domain PF00195 (Chalcone and stilbene synthases, N-terminal domain) in Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4jaq_1_A_Pfam_PF00195_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jaq</span> contains 4 copies of Pfam domain <span class='highlight'>PF00195 (Chalcone and stilbene synthases, N-terminal domain)</span> in <span class='highlight'>Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 4jaq contains 8 copies of CATH domain 3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1) in Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11. Showing 2 copies in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4jaq_1_A_CATH_3.40.47.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4jaq</span> contains 8 copies of CATH domain <span class='highlight'>3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1)</span> in <span class='highlight'>Methyl-branched alkylpyrone synthesis polyketide synthase-like Pks11</span>. Showing 2 copies in chain <span class='highlight'>B [auth A]</span>.")