› 4jhn

X-ray diffraction
1.7Å resolution

The crystal structure of the RPGR RCC1-like domain

Released:
DOI: 10.2210/pdb4jhn/pdb
PDB entry 4jhn coloured by chain, front view.
PDB entry 4jhn coloured by chain, side view.
PDB entry 4jhn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Wätzlich D, Vetter I, Gotthardt K, Miertzschke M, Chen YX, Wittinghofer A, Ismail S
EMBO Rep 14 465-72 (2013)
PMID: 23559067

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187772 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
X-linked retinitis pigmentosa GTPase regulator Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 421 amino acids
Theoretical weight: 45.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92834 (Residues: 1-392; Coverage: 38%)
Gene names: RP3, RPGR, XLRP3
Sequence domains: Regulator of chromosome condensation (RCC1) repeat
Structure domains: Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 57.49Å b: 118.73Å c: 92.63Å
α: 90° β: 101.54° γ: 90°
R-values:
R R work R free
0.187 0.185 0.218
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition.
Garcia-Gonzalo et al. (2017)
10 more

3 mentions without citation

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Wätzlich et al. (2013)
2 more