› 4joc

X-ray diffraction
2.21Å resolution

Crystal structure of human lysophosphatidic acid phosphatase type 6 complexed with Malonate

Released:
DOI: 10.2210/pdb4joc/pdb
PDB entry 4joc coloured by chain, front view.
PDB entry 4joc coloured by chain, side view.
PDB entry 4joc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6.
Li J, Dong Y, Lü X, Wang L, Peng W, Zhang XC, Rao Z
Protein Cell 4 548-61 (2013)
PMID: 23807634

Function and Biology Details

Reaction catalysed: 
A phosphate monoester + H(2)O = an alcohol + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192482 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysophosphatidic acid phosphatase type 6 Chain: A
Molecule details ›
Chain: A
Length: 396 amino acids
Theoretical weight: 45.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NPH0 (Residues: 33-428; Coverage: 93%)
Gene names: ACP6, ACPL1, LPAP, UNQ205/PRO231
Sequence domains: Histidine phosphatase superfamily (branch 2)
Structure domains: Phosphoglycerate mutase-like

Ligands and Environments

1 bound ligand:
Ligand MLA 1 x MLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 42.622Å b: 87.949Å c: 90.146Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.223
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma.
Zhu et al. (2017)
4 more

1 mention without citation

Structure-Function Relationship Study of a Secretory Amoebic Phosphatase: A Computational-Experimental Approach.
Terán-Ramírez et al. (2021)