› 4jy6

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PGT123 light chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 211 amino acids
Theoretical weight: 22.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Structure domains: Immunoglobulins
PGT123 heavy chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 235 amino acids
Theoretical weight: 25.17 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand ZN 18 x ZN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 84.89Å b: 80.32Å c: 90.43Å
α: 90° β: 93.85° γ: 90°
R-values:
R R work R free
0.21 0.207 0.265
Expression system: Spodoptera frugiperda

Quick links

Citations

51 review citations

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design.
Burton et al. (2016)
50 more

2 mentions without citation

Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Julien et al. (2013)
1 more