› 4jza

X-ray diffraction
2.58Å resolution

Crystal structure of a Legionella phosphoinositide phosphatase: insights into lipid metabolism in pathogen host interaction

Released:
DOI: 10.2210/pdb4jza/pdb
PDB entry 4jza coloured by chain, front view.
PDB entry 4jza coloured by chain, side view.
PDB entry 4jza coloured by chain, top view.
Source organism: Legionella longbeachae NSW150
Primary publication:
Identification and structural characterization of a Legionella phosphoinositide phosphatase.
Toulabi L, Wu X, Cheng Y, Mao Y
J Biol Chem 288 24518-27 (2013)
PMID: 23843460

Function and Biology Details

Reaction catalysed: 
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-112498 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxidoreductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 825 amino acids
Theoretical weight: 95.05 KDa
Source organism: Legionella longbeachae NSW150
UniProt:
  • Canonical: D3HMN4 (Residues: 1-825; Coverage: 100%)
Gene name: LLO_3270
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 22 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 89.28Å b: 119.653Å c: 133.533Å
α: 90° β: 101.33° γ: 90°
R-values:
R R work R free
0.198 0.196 0.237

Quick links

Citations

24 review citations

Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones.
Finsel et al. (2015)
23 more

3 mentions without citation

Identification and structural characterization of a Legionella phosphoinositide phosphatase.
Toulabi et al. (2013)
2 more