Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Proprotein convertase subtilisin/kexin type 9 (preferred)
PDBe Complex ID:
PDB-CPX-185469 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Proprotein convertase subtilisin/kexin type 9
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Length: 92 amino acids
Theoretical weight: 10.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q8NBP7 (Residues: 61-152; Coverage: 14%)
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Proprotein convertase subtilisin/kexin type 9
Molecule details ›
Chain: B
Length: 548 amino acids
Theoretical weight: 58.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 548 amino acids
Theoretical weight: 58.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q8NBP7 (Residues: 153-692; Coverage: 82%)
Sequence domains:
- Subtilase family
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
- Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X06SA
Spacegroup:
C2
Expression system: Escherichia coli
