› 4kxz

X-ray diffraction
2.83Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211469 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Transforming growth factor beta-2 Chains: A, B, D, E
Molecule details ›
Chains: A, B, D, E
Length: 112 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61812 (Residues: 303-414; Coverage: 28%)
Gene name: TGFB2
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
GC1008 Heavy Chain Chains: H, J, N, Q
Molecule details ›
Chains: H, J, N, Q
Length: 224 amino acids
Theoretical weight: 23.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
GC1008 Light Chain Chains: I, L, M, P
Molecule details ›
Chains: I, L, M, P
Length: 215 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand MES 5 x MES
Ligand PE5 1 x PE5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21212
Unit cell:
a: 131.2Å b: 359.68Å c: 64.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.183 0.222
Expression systems:
  • Escherichia coli
  • Homo sapiens

Quick links

Citations

2 review citations

TGF-beta signal transduction: biology, function and therapy for diseases.
Tie et al. (2022)
1 more

6 mentions without citation

A Bibliometric and In Silico-Based Analysis of Anti-Lung Cancer Compounds from Sea Cucumber.
Zare et al. (2023)
5 more