› 4kzi

X-ray diffraction
2.41Å resolution

Crystal Structure of TR3 LBD in complex with DPDO

Released:
DOI: 10.2210/pdb4kzi/pdb
PDB entry 4kzi coloured by chain, front view.
PDB entry 4kzi coloured by chain, side view.
PDB entry 4kzi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Wang WJ, Wang Y, Chen HZ, Xing YZ, Li FW, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu M, Han J, Huang PQ, Lin T, Wu Q
Nat Chem Biol 10 133-40 (2014)
PMID: 24316735

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 4immunitygroup A member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 28.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22736 (Residues: 351-598; Coverage: 42%)
Gene names: GFRP1, HMR, NAK1, NR4A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand ZJ0 1 x ZJ0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 74.723Å b: 76.512Å c: 128.918Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.249
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.
Fulda et al. (2015)
25 more

1 mention without citation

PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy.
Wang et al. (2024)