› 4l59

X-ray diffraction
2.29Å resolution

Crystal structure of the 3-MBT repeat domain of L3MBTL3 and UNC2533 complex

Released:
DOI: 10.2210/pdb4l59/pdb
PDB entry 4l59 coloured by chain, front view.
PDB entry 4l59 coloured by chain, side view.
PDB entry 4l59 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.
Camerino MA, Zhong N, Dong A, Dickson BM, James LI, Baughman BM, Norris JL, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV
Medchemcomm 4 1501-1507 (2013)
PMID: 24466405

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lethal(3)malignant brain tumor-like protein 3 Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 36.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96JM7 (Residues: 228-544; Coverage: 41%)
Gene names: KIAA1798, L3MBTL3, MBT1
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

3 bound ligands:
Ligand 1VZ 1 x 1VZ
Ligand SO4 1 x SO4
Ligand UNX 12 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 104.798Å b: 104.798Å c: 110.644Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.212 0.25
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Epigenetic targets and drug discovery: part 1: histone methylation.
Liu et al. (2014)
5 more

2 mentions without citation

The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.
Camerino et al. (2013)
1 more