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Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor

X-ray diffraction
1.94Å resolution
PDB entry 4l5b coloured by chain, front view.
PDB entry 4l5b coloured by chain, side view.
PDB entry 4l5b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Deoxycytidine kinase
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Multimeric state: homo dimer
Accessible surface area: 20388.01 Å2
Buried surface area: 3858.76 Å2
Dissociation area: 1,225.39 Å2
Dissociation energy (ΔGdiss): 10.77 kcal/mol
Dissociation entropy (TΔSdiss): 13.03 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151058

Macromolecules

Deoxycytidine kinase
Chains: A, B
Length: 280 amino acids
Theoretical weight: 32.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P27707 (Residues: 1-260; Coverage: 100%)
Gene name: DCK
Pfam: Deoxynucleoside kinase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Deoxycytidine kinase in PDB entry 4l5b, assembly 1, front view.
Deoxycytidine kinase in PDB entry 4l5b, assembly 1, side view.
Deoxycytidine kinase in PDB entry 4l5b, assembly 1, top view.
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