Function and Biology Details
Reactions catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- Phosphotyrosyl phosphatase activator, PTPA
- HEAT, type 2
- Metallo-dependent phosphatase-like
- Calcineurin-like phosphoesterase domain, ApaH type
- Serine/Threonine protein phosphatase PP2A-like
- Phosphotyrosyl phosphatase activator, C-terminal lid domain
- PTPA superfamily
3 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-151666 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Serine/threonine-protein phosphatase 2A activator
Molecule details ›
Chain: B
Length: 308 amino acids
Theoretical weight: 35.19 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Phosphotyrosyl phosphate activator (PTPA) protein
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)
Length: 308 amino acids
Theoretical weight: 35.19 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q15257 (Residues: 19-358; Coverage: 85%)
Sequence domains: Phosphotyrosyl phosphate activator (PTPA) protein
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 28.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: HEAT repeat
Structure domains: Leucine-rich Repeat Variant
Length: 258 amino acids
Theoretical weight: 28.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P30153 (Residues: 366-589; Coverage: 38%)
Sequence domains: HEAT repeat
Structure domains: Leucine-rich Repeat Variant
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Molecule details ›
Chain: C
Length: 311 amino acids
Theoretical weight: 35.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Length: 311 amino acids
Theoretical weight: 35.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P67775 (Residues: 1-309; Coverage: 100%)
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
