› 4ll0

X-ray diffraction
4Å resolution

EGFR L858R/T790M in complex with PD168393

Released:
DOI: 10.2210/pdb4ll0/pdb
PDB entry 4ll0 coloured by chain, front view.
PDB entry 4ll0 coloured by chain, side view.
PDB entry 4ll0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.
Red Brewer M, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W
Proc Natl Acad Sci U S A 110 E3595-604 (2013)
PMID: 24019492

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 331 amino acids
Theoretical weight: 37.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 694-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand YUN 2 x YUN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 61.64Å b: 72.71Å c: 167.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.257
Expression system: Spodoptera frugiperda

Quick links

Citations

17 review citations

The ErbB/HER family of protein-tyrosine kinases and cancer.
Roskoski R. (2014)
16 more

9 mentions without citation

A structural perspective on the regulation of the epidermal growth factor receptor.
Kovacs et al. (2015)
8 more