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Crystal structure of a topoisomerase ATP inhibitor

Source organism: Streptococcus pneumoniae R6
Biochemical function: ATP binding
Biological process: DNA topological change
Cellular component: not assigned

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EC 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing)

Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Systematic name:
DNA topoisomerase (ATP-hydrolyzing)
Alternative Name(s):
  • DNA gyrase
  • DNA topoisomerase II
  • Type II DNA topoisomerase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02518
Domain description: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Occurring in:
  1. DNA topoisomerase 4 subunit B
The deposited structure of PDB entry 4lp0 contains 1 copy of Pfam domain PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) in DNA topoisomerase 4 subunit B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000565
Domain description: DNA topoisomerase, type IIA, subunit B
Occurring in:
  1. DNA topoisomerase 4 subunit B
IPR003594
Domain description: Histidine kinase/HSP90-like ATPase
Occurring in:
  1. DNA topoisomerase 4 subunit B
IPR036890
Domain description: Histidine kinase/HSP90-like ATPase superfamily
Occurring in:
  1. DNA topoisomerase 4 subunit B
IPR001241
Domain description: DNA topoisomerase, type IIA
Occurring in:
  1. DNA topoisomerase 4 subunit B

Structure domain

CATH CATH domain
3.30.565.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Heat Shock Protein 90
Homology: Histidine kinase-like ATPase, C-terminal domain
Occurring in:
  1. DNA topoisomerase 4 subunit B
The deposited structure of PDB entry 4lp0 contains 1 copy of CATH domain 3.30.565.10 (Heat Shock Protein 90) in DNA topoisomerase 4 subunit B. Showing 1 copy in chain A.

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