› 4m67

X-ray diffraction
1.9Å resolution

Crystal structure of the human MLKL kinase-like domain

Released:
DOI: 10.2210/pdb4m67/pdb
PDB entry 4m67 coloured by chain, front view.
PDB entry 4m67 coloured by chain, side view.
PDB entry 4m67 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into RIP3-mediated necroptotic signaling.
Xie T, Peng W, Yan C, Wu J, Gong X, Shi Y
Cell Rep 5 70-8 (2013)
PMID: 24095729

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185458 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mixed lineage kinase domain-like protein Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 33.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NB16 (Residues: 179-471; Coverage: 62%)
Gene name: MLKL
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2221
Unit cell:
a: 71.499Å b: 75.12Å c: 126.817Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.225
Expression system: Escherichia coli

Quick links

Citations

44 review citations

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
Vanden Berghe et al. (2014)
43 more

7 mentions without citation

Structural Basis for the Non-catalytic Functions of Protein Kinases.
Kung et al. (2016)
6 more