› 4m6w

X-ray diffraction
2.9Å resolution

Crystal structure of the C-terminal segment of FANCM in complex with FAAP24

Released:
DOI: 10.2210/pdb4m6w/pdb
PDB entry 4m6w coloured by chain, front view.
PDB entry 4m6w coloured by chain, side view.
PDB entry 4m6w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair.
Yang H, Zhang T, Tao Y, Wang F, Tong L, Ding J
Nucleic Acids Res 41 10573-83 (2013)
PMID: 24003026

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184940 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fanconi anemia group M protein Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IYD8 (Residues: 1813-2031; Coverage: 11%)
Gene names: FANCM, KIAA1596
Sequence domains: ERCC4 domain
Structure domains:
Fanconi anemia core complex-associated protein 24 Chain: B
Molecule details ›
Chain: B
Length: 208 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BTP7 (Residues: 17-215; Coverage: 93%)
Gene names: C19orf40, FAAP24
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I222
Unit cell:
a: 79.174Å b: 98.111Å c: 140.156Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.254 0.299
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Fanconi Anemia Signaling and Cancer.
Nepal et al. (2017)
3 more

2 mentions without citation

Fanconi anemia pathway as a prospective target for cancer intervention.
Liu et al. (2020)
1 more