› 4mhl

X-ray diffraction
2.09Å resolution

The crystal structure of human interleukin-11

Released:
DOI: 10.2210/pdb4mhl/pdb
PDB entry 4mhl coloured by chain, front view.
PDB entry 4mhl coloured by chain, side view.
PDB entry 4mhl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.
Putoczki TL, Dobson RC, Griffin MD
Acta Crystallogr D Biol Crystallogr 70 2277-85 (2014)
PMID: 25195742

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149065 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-11 Chain: A
Molecule details ›
Chain: A
Length: 177 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20809 (Residues: 23-199; Coverage: 99%)
Gene name: IL11
Sequence domains: Interleukin 11
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand ARF 5 x ARF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21212
Unit cell:
a: 118.862Å b: 28.169Å c: 41.806Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.184 0.242
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Mast cells as sources of cytokines, chemokines, and growth factors.
Mukai et al. (2018)
5 more

5 mentions without citation

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.
Metcalfe et al. (2020)
4 more