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E. coli sliding clamp in complex with Bromfenac

Source organism: Escherichia coli K-12
Biochemical function: protein homodimerization activity
Biological process: bacterial-type DNA replication
Cellular component: Hda-beta clamp complex

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EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02768
Domain description: DNA polymerase III beta subunit, C-terminal domain
Occurring in:
  1. Beta sliding clamp
The deposited structure of PDB entry 4mjq contains 2 copies of Pfam domain PF02768 (DNA polymerase III beta subunit, C-terminal domain) in Beta sliding clamp. Showing 1 copy in chain B.

PF02767
Domain description: DNA polymerase III beta subunit, central domain
Occurring in:
  1. Beta sliding clamp
The deposited structure of PDB entry 4mjq contains 2 copies of Pfam domain PF02767 (DNA polymerase III beta subunit, central domain) in Beta sliding clamp. Showing 1 copy in chain B.

PF00712
Domain description: DNA polymerase III beta subunit, N-terminal domain
Occurring in:
  1. Beta sliding clamp
The deposited structure of PDB entry 4mjq contains 2 copies of Pfam domain PF00712 (DNA polymerase III beta subunit, N-terminal domain) in Beta sliding clamp. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR046938
Domain description: DNA clamp superfamily
Occurring in:
  1. Beta sliding clamp
IPR001001
Domain description: DNA polymerase III, beta sliding clamp
Occurring in:
  1. Beta sliding clamp
IPR022635
Domain description: DNA polymerase III, beta sliding clamp, C-terminal
Occurring in:
  1. Beta sliding clamp
IPR022637
Domain description: DNA polymerase III, beta sliding clamp, central
Occurring in:
  1. Beta sliding clamp
IPR022634
Domain description: DNA polymerase III, beta sliding clamp, N-terminal
Occurring in:
  1. Beta sliding clamp

Structure domain

CATH CATH domain
3.10.150.10
Class: Alpha Beta
Architecture: Roll
Topology: DNA Polymerase III; Chain A, domain 2
Homology: DNA Polymerase III, subunit A, domain 2
Occurring in:
  1. Beta sliding clamp
The deposited structure of PDB entry 4mjq contains 6 copies of CATH domain 3.10.150.10 (DNA Polymerase III; Chain A, domain 2) in Beta sliding clamp. Showing 3 copies in chain B.

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