4mn3

X-ray diffraction
1.54Å resolution

Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-132082 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Chromobox protein homolog 7 Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95931 (Residues: 7-62; Coverage: 22%)
Gene name: CBX7
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
peptide Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 682 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 63.29Å b: 31.86Å c: 38.39Å
α: 90° β: 119.02° γ: 90°
R-values:
R R work R free
0.174 0.172 0.213
Expression systems:
  • Escherichia coli
  • Not provided