› 4msl

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189211 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Sortilin Chain: A
Molecule details ›
Chain: A
Length: 696 amino acids
Theoretical weight: 77.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99523 (Residues: 78-756; Coverage: 85%)
Gene name: SORT1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand PG4 1 x PG4
Ligand 2ET 1 x 2ET
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 160.876Å b: 79.165Å c: 111.7Å
α: 90° β: 127.27° γ: 90°
R-values:
R R work R free
0.206 0.205 0.227
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Goettsch et al. (2018)
1 more

3 mentions without citation

Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.
Andersen et al. (2014)
2 more