› 4mt1

X-ray diffraction
3.54Å resolution

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump

Released:
DOI: 10.2210/pdb4mt1/pdb
PDB entry 4mt1 coloured by chain, front view.
PDB entry 4mt1 coloured by chain, side view.
PDB entry 4mt1 coloured by chain, top view.
Source organism: Neisseria gonorrhoeae PID332
Primary publication:
Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel.
Lei HT, Chou TH, Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Do SV, Rajashankar KR, Shafer WM, Yu EW
PLoS One 9 e97475 (2014)
PMID: 24901251

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: R32
Unit cell:
a: 152.995Å b: 152.995Å c: 360.746Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.282 0.28 0.333
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.
Li et al. (2015)
10 more

14 mentions without citation

Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies.
Symmons et al. (2015)
13 more