› 4mtz

X-ray diffraction
2.1Å resolution

Structure of XIAP-BIR1 in complex with NF023

Released:
DOI: 10.2210/pdb4mtz/pdb
PDB entry 4mtz coloured by chain, front view.
PDB entry 4mtz coloured by chain, side view.
PDB entry 4mtz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Cossu F, Milani M, Grassi S, Mastrangelo E, Bolognesi M

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase XIAP Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 111 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P98170 (Residues: 10-99; Coverage: 18%)
Gene names: API3, BIRC4, IAP3, XIAP
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand SO4 1 x SO4
Ligand 0BU 2 x 0BU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 36.854Å b: 76.209Å c: 71.191Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.242
Expression system: Escherichia coli

Quick links