› 4n6h

X-ray diffraction
1.8Å resolution

1.8 A Structure of the human delta opioid 7TM receptor (PSI Community Target)

Released:
DOI: 10.2210/pdb4n6h/pdb
PDB entry 4n6h coloured by chain, front view.
PDB entry 4n6h coloured by chain, side view.
PDB entry 4n6h coloured by chain, top view.
Source organisms:
Primary publication:
Molecular control of δ-opioid receptor signalling.
Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC
Nature 506 191-6 (2014)
PMID: 24413399

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142081 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Delta-type opioid receptor; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 414 amino acids
Theoretical weight: 45.88 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: P41143 (Residues: 36-338; Coverage: 82%)
Gene names: OPRD, OPRD1, cybC
Sequence domains:
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand OLA 12 x OLA
Ligand OLC 5 x OLC
Ligand PGE 3 x PGE
Ligand TLA 1 x TLA
Ligand EJ4 1 x EJ4
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 86.23Å b: 72.851Å c: 84.408Å
α: 90° β: 107.48° γ: 90°
R-values:
R R work R free
0.173 0.172 0.19
Expression system: Spodoptera frugiperda

Quick links

Citations

70 review citations

DREADDs for Neuroscientists.
Roth BL. (2016)
69 more

125 mentions without citation

The Molecular Basis of G Protein-Coupled Receptor Activation.
Weis et al. (2018)
124 more