› 4nah

X-ray diffraction
2.38Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphopantetheine adenylyltransferase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 160 amino acids
Theoretical weight: 18.4 KDa
Source organism: Staphylococcus aureus subsp. aureus MW2
Expression system: Escherichia coli
UniProt:
  • Canonical: P63820 (Residues: 1-160; Coverage: 100%)
Gene names: MW1007, coaD
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

2 bound ligands:
Ligand AGS 6 x AGS
Ligand 2VJ 6 x 2VJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 68.476Å b: 105.36Å c: 79.98Å
α: 90° β: 94.69° γ: 90°
R-values:
R R work R free
0.22 0.216 0.292
Expression system: Escherichia coli

Quick links

Citations

9 review citations

ESKAPEing the labyrinth of antibacterial discovery.
Tommasi et al. (2015)
8 more

1 mention without citation

Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
de Jonge et al. (2013)