› 4nau

X-ray diffraction
2.33Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphopantetheine adenylyltransferase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 160 amino acids
Theoretical weight: 18.4 KDa
Source organism: Staphylococcus aureus subsp. aureus MW2
Expression system: Escherichia coli
UniProt:
  • Canonical: P63820 (Residues: 1-160; Coverage: 100%)
Gene names: MW1007, coaD
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

2 bound ligands:
Ligand AGS 3 x AGS
Ligand 2W3 1 x 2W3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 77.095Å b: 127.782Å c: 127.123Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.256 0.32
Expression system: Escherichia coli

Quick links

Citations

9 review citations

ESKAPEing the labyrinth of antibacterial discovery.
Tommasi et al. (2015)
8 more

2 mentions without citation

Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
de Jonge et al. (2013)
1 more