› 4nrc

X-ray diffraction
1.86Å resolution

Crystal Structure of the bromodomain of human BAZ2B in complex with compound-3 N01186

Released:
DOI: 10.2210/pdb4nrc/pdb
PDB entry 4nrc coloured by chain, front view.
PDB entry 4nrc coloured by chain, side view.
PDB entry 4nrc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.
Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A
J Med Chem 56 10183-7 (2013)
PMID: 24304323

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193783 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2B Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF8 (Residues: 2054-2168; Coverage: 5%)
Gene names: BAZ2B, KIAA1476
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

3 bound ligands:
Ligand 2LY 1 x 2LY
Ligand EDO 2 x EDO
Ligand 15P 1 x 15P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: C2221
Unit cell:
a: 81.27Å b: 96.59Å c: 57.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.191
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Targeting bromodomains: epigenetic readers of lysine acetylation.
Filippakopoulos et al. (2014)
12 more

2 mentions without citation

Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.
Ferguson et al. (2013)
1 more