› 4o1o

X-ray diffraction
3.27Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107595 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease L Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 717 amino acids
Theoretical weight: 81.33 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: A5H025 (Residues: 21-732; Coverage: 96%)
Gene name: RNASEL
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 25L 4 x 25L
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 59.792Å b: 111.968Å c: 268.465Å
α: 90° β: 90.03° γ: 90°
R-values:
R R work R free
0.232 0.23 0.289
Expression system: Escherichia coli

Quick links

Citations

24 review citations

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.
Hornung et al. (2014)
23 more

3 mentions without citation

Prospects for pharmacological targeting of pseudokinases.
Kung et al. (2019)
2 more