Function and Biology Details
Reaction catalysed:
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Kallikrein complex (preferred)
PDBe Complex ID:
PDB-CPX-137295 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Plasma kallikrein light chain
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 27.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 241 amino acids
Theoretical weight: 27.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P03952 (Residues: 391-631; Coverage: 39%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Ig-like domain-containing protein
Molecule details ›
Chain: H
Length: 225 amino acids
Theoretical weight: 24.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Structure domains: Immunoglobulins
Length: 225 amino acids
Theoretical weight: 24.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: S6C4R2 (Residues: 20-244; Coverage: 88%)
Structure domains: Immunoglobulins
Ig-like domain-containing protein
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Structure domains: Immunoglobulins
Length: 213 amino acids
Theoretical weight: 23.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q7Z3Y4 (Residues: 23-236; Coverage: 100%)
Structure domains: Immunoglobulins
