› 4oi9

X-ray diffraction
2.5Å resolution

Crystal Structure of ICAM-5 D1-D4 ectodomain fragment, Space Group P21

Released:
DOI: 10.2210/pdb4oi9/pdb
PDB entry 4oi9 coloured by chain, front view.
PDB entry 4oi9 coloured by chain, side view.
PDB entry 4oi9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions.
Recacha R, Jiménez D, Tian L, Barredo R, Gahmberg CG, Casasnovas JM
Acta Crystallogr D Biol Crystallogr 70 1934-43 (2014)
PMID: 25004970

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193965 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Intercellular adhesion molecule 5 Chain: A
Molecule details ›
Chain: A
Length: 378 amino acids
Theoretical weight: 41.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UMF0 (Residues: 32-409; Coverage: 42%)
Gene names: ICAM5, TLCN, TLN
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 5 x NAG
Ligand EDO 31 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM16
Spacegroup: P21
Unit cell:
a: 76.59Å b: 46.91Å c: 95.79Å
α: 90° β: 104.34° γ: 90°
R-values:
R R work R free
0.251 0.248 0.263
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Stable mammalian producer cell lines for structural biology.
Büssow K. (2015)
5 other articles

1 mention without citation

Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions.
Recacha et al. (2014)