› 4oia

X-ray diffraction
3.7Å resolution

Crystal Structure of ICAM-5 D1-D4 ectodomain fragment, Space Group P4322

Released:
DOI: 10.2210/pdb4oia/pdb
PDB entry 4oia coloured by chain, front view.
PDB entry 4oia coloured by chain, side view.
PDB entry 4oia coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions.
Recacha R, Jiménez D, Tian L, Barredo R, Gahmberg CG, Casasnovas JM
Acta Crystallogr D Biol Crystallogr 70 1934-43 (2014)
PMID: 25004970

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193965 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Intercellular adhesion molecule 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 378 amino acids
Theoretical weight: 41.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UMF0 (Residues: 32-409; Coverage: 42%)
Gene names: ICAM5, TLCN, TLN
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 6 x NAG
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P4322
Unit cell:
a: 96.07Å b: 96.07Å c: 321.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.23 0.28
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Stable mammalian producer cell lines for structural biology.
Büssow K. (2015)
5 other articles

2 mentions without citation

Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions.
Recacha et al. (2014)
1 more