› 4p3f

X-ray diffraction
1.7Å resolution

Structure of the human SRP68-RBD

Released:
DOI: 10.2210/pdb4p3f/pdb
PDB entry 4p3f coloured by chain, front view.
PDB entry 4p3f coloured by chain, side view.
PDB entry 4p3f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
SRP RNA remodeling by SRP68 explains its role in protein translocation.
Grotwinkel JT, Wild K, Segnitz B, Sinning I
Science 344 101-4 (2014)
PMID: 24700861

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193736 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Signal recognition particle subunit SRP68 Chains: A, B
Molecule details ›
Chains: A, B
Length: 216 amino acids
Theoretical weight: 25.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHB9 (Residues: 47-254; Coverage: 33%)
Gene name: SRP68
Sequence domains: RNA-binding signal recognition particle 68
Structure domains: Signal recognition particle, SRP68 subunit, RNA-binding domain

Ligands and Environments

2 bound ligands:
Ligand PEG 3 x PEG
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 37.81Å b: 93.31Å c: 60.1Å
α: 90° β: 109.34° γ: 90°
R-values:
R R work R free
0.178 0.176 0.219
Expression system: Escherichia coli

Quick links

Citations

6 review citations

POLIII-derived non-coding RNAs acting as scaffolds and decoys.
Täuber et al. (2019)
5 more

2 mentions without citation

Signal Recognition Particle in Human Diseases.
Kellogg et al. (2022)
1 more