4p5m

X-ray diffraction
1.7Å resolution

Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between Allergic Hypersensitivity and Autoimmunity

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-137850 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (7 distinct):
HLA class II histocompatibility antigen, DP alpha 1 chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 183 amino acids
Theoretical weight: 21.17 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P20036 (Residues: 32-214; Coverage: 79%)
Gene names: HLA-DP1A, HLA-DPA1, HLASB
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DP beta 1 chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 212 amino acids
Theoretical weight: 24.34 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P04440 (Residues: 13-16, 32-218; Coverage: 76%)
Gene names: HLA-DP1B, HLA-DPB1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 81.631Å b: 130.468Å c: 107.994Å
α: 90° β: 107.16° γ: 90°
R-values:
R R work R free
0.17 0.168 0.204
Expression system: Trichoplusia ni