› 4pch

X-ray diffraction
1.7Å resolution

Structure of Human Polyomavirus 7 (HPyV7) VP1 pentamer

Released:
DOI: 10.2210/pdb4pch/pdb
PDB entry 4pch coloured by chain, front view.
PDB entry 4pch coloured by chain, side view.
PDB entry 4pch coloured by chain, top view.
Source organism: Human polyomavirus 7
Primary publication:
Structure analysis of the major capsid proteins of human polyomaviruses 6 and 7 reveals an obstructed sialic acid binding site.
Ströh LJ, Neu U, Blaum BS, Buch MH, Garcea RL, Stehle T
J Virol 88 10831-9 (2014)
PMID: 25008942

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
VP1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 273 amino acids
Theoretical weight: 29.31 KDa
Source organism: Human polyomavirus 7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: D6QWK5 (Residues: 21-288; Coverage: 71%)
Sequence domains: Polyomavirus coat protein
Structure domains: Capsid protein VP1,Polyomavirus

Ligands and Environments

1 bound ligand:
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 209.67Å b: 86.43Å c: 84.21Å
α: 90° β: 92.14° γ: 90°
R-values:
R R work R free
0.171 0.169 0.197
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Metabolic Glycoengineering with N-Acyl Side Chain Modified Mannosamines.
Wratil et al. (2016)
5 more

2 mentions without citation

Structure analysis of the major capsid proteins of human polyomaviruses 6 and 7 reveals an obstructed sialic acid binding site.
Ströh et al. (2014)
1 more