› 4ped

X-ray diffraction
1.64Å resolution

Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthes

Released:
DOI: 10.2210/pdb4ped/pdb
PDB entry 4ped coloured by chain, front view.
PDB entry 4ped coloured by chain, side view.
PDB entry 4ped coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.
Stefely JA, Reidenbach AG, Ulbrich A, Oruganty K, Floyd BJ, Jochem A, Saunders JM, Johnson IE, Minogue CE, Wrobel RL, Barber GE, Lee D, Li S, Kannan N, Coon JJ, Bingman CA, Pagliarini DJ
Mol Cell 57 83-94 (2015)
PMID: 25498144

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185573 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Atypical kinase COQ8A, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 393 amino acids
Theoretical weight: 45.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NI60 (Residues: 256-647; Coverage: 61%)
Gene names: ADCK3, CABC1, COQ8A, PP265
Sequence domains: ABC1 atypical kinase-like domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
1 modified residue:
Ligand MSE 15 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2
Unit cell:
a: 148.671Å b: 54.557Å c: 45.009Å
α: 90° β: 94° γ: 90°
R-values:
R R work R free
0.167 0.165 0.211
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Phosphoproteomics in the Age of Rapid and Deep Proteome Profiling.
Riley et al. (2016)
18 more

15 mentions without citation

Biochemistry of Mitochondrial Coenzyme Q Biosynthesis.
Stefely et al. (2017)
14 more