› 4pmi

X-ray diffraction
3.2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assemblies composition:
hetero nonamer (preferred)
hetero octadecamer
Assembly name:
PDBe Complex ID:
PDB-CPX-159645 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Protein Rev Chains: B, C
Molecule details ›
Chains: B, C
Length: 72 amino acids
Theoretical weight: 8.38 KDa
Source organism: Human immunodeficiency virus type 1 (HXB3 ISOLATE)
Expression system: Escherichia coli
UniProt:
  • Canonical: P69718 (Residues: 1-70; Coverage: 60%)
Gene name: rev
Sequence domains: REV protein (anti-repression trans-activator protein)
Structure domains: Helix Hairpins
Rev-Response-Element RNA Chain: A
Molecule details ›
Chain: A
Length: 40 nucleotides
Theoretical weight: 12.94 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P4132
Unit cell:
a: 165.3Å b: 165.3Å c: 165.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.211
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

9 review citations

HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective.
Rausch et al. (2015)
8 more

15 mentions without citation

The new (dis)order in RNA regulation.
Järvelin et al. (2016)
14 more