› 4pn6

X-ray diffraction
3Å resolution

Structure of the Cytomegalovirus-Encoded m04 Glycoprotein

Released:
DOI: 10.2210/pdb4pn6/pdb
PDB entry 4pn6 coloured by chain, front view.
PDB entry 4pn6 coloured by chain, side view.
PDB entry 4pn6 coloured by chain, top view.
Source organism: Muromegalovirus G4
Primary publication:
The structure of the cytomegalovirus-encoded m04 glycoprotein, a prototypical member of the m02 family of immunoevasins.
Berry R, Vivian JP, Deuss FA, Balaji GR, Saunders PM, Lin J, Littler DR, Brooks AG, Rossjohn J
J Biol Chem 289 23753-63 (2014)
PMID: 24982419

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109941 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
M04 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 24.02 KDa
Source organism: Muromegalovirus G4
Expression system: Homo sapiens
UniProt:
  • Canonical: B3UWV7 (Residues: 24-224; Coverage: 76%)
Gene name: m04
Sequence domains: Immune evasion protein
Structure domains: Immunoglobulin-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P41212
Unit cell:
a: 94.04Å b: 94.04Å c: 122.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.221 0.243
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Modulation of innate and adaptive immunity by cytomegaloviruses.
Berry et al. (2020)
7 other articles

3 mentions without citation

Chemical shift-based methods in NMR structure determination.
Nerli et al. (2018)
2 more