› 4pzq

X-ray diffraction
2.24Å resolution

Crystal Structure of CCG DNA repeats

Released:
DOI: 10.2210/pdb4pzq/pdb
PDB entry 4pzq coloured by chain, front view.
PDB entry 4pzq coloured by chain, side view.
PDB entry 4pzq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats.
Chen YW, Jhan CR, Neidle S, Hou MH
Angew Chem Int Ed Engl 53 10682-6 (2014)
PMID: 25139267

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117996 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*CP*CP*GP*CP*CP*GP*CP*CP*GP*A)-3') Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.3 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CO 2 x CO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P43212
Unit cell:
a: 38.145Å b: 38.145Å c: 54.249Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.235 0.257
Expression system: Not provided

Quick links

Citations

1 review citation

A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding.
Satange et al. (2018)
12 other articles

3 mentions without citation

Molecular conformations and dynamics of nucleotide repeats associated with neurodegenerative diseases: double helices and CAG hairpin loops.
Pan et al. (2021)
2 more