› 4qmj

X-ray diffraction
2.5Å resolution

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array

Released:
DOI: 10.2210/pdb4qmj/pdb
PDB entry 4qmj coloured by chain, front view.
PDB entry 4qmj coloured by chain, side view.
PDB entry 4qmj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.
Fox JC, Howard AE, Currie JD, Rogers SL, Slep KC
Mol Biol Cell 25 2375-92 (2014)
PMID: 24966168

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171898 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoskeleton-associated protein 5 Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 27.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14008 (Residues: 846-1081; Coverage: 12%)
Gene names: CKAP5, KIAA0097
Sequence domains: CLASP N terminal
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 79.125Å b: 79.125Å c: 68.499Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.208 0.276
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Control of microtubule organization and dynamics: two ends in the limelight.
Akhmanova et al. (2015)
5 more

1 mention without citation

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.
Fox et al. (2014)