› 4qq4

X-ray diffraction
1.75Å resolution

CW-type zinc finger of MORC3 in complex with the amino terminus of histone H3

Released:
DOI: 10.2210/pdb4qq4/pdb
PDB entry 4qq4 coloured by chain, front view.
PDB entry 4qq4 coloured by chain, side view.
PDB entry 4qq4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins.
Liu Y, Tempel W, Zhang Q, Liang X, Loppnau P, Qin S, Min J
J Biol Chem 291 9000-13 (2016)
PMID: 26933034

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160871 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
MORC family CW-type zinc finger protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 62 amino acids
Theoretical weight: 7.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14149 (Residues: 400-460; Coverage: 7%)
Gene names: KIAA0136, MORC3, NXP2, ZCWCC3
Sequence domains: CW-type Zinc Finger
Structure domains: Herpes Virus-1
Histone H3.3 Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P84243 (Residues: 2-16; Coverage: 11%)
Gene names: H3-3A, H3-3B, H3.3A, H3.3B, H3F3, H3F3A, H3F3B, PP781

Ligands and Environments

3 bound ligands:
Ligand ZN 3 x ZN
Ligand UNX 7 x UNX
Ligand CL 2 x CL
1 modified residue:
Ligand M3L 2 x M3L

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 62.622Å b: 64.86Å c: 36.015Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.18 0.223
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

6 review citations

Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.
Niwa et al. (2017)
5 more

4 mentions without citation

Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins.
Liu et al. (2016)
3 more