› 4qzt

X-ray diffraction
1.9Å resolution

Crystal Structure of wild type Human Cellular Retinol Binding Protein II (hCRBPII) bound to retinol at 7 KeV beam energy

Released:
DOI: 10.2210/pdb4qzt/pdb
PDB entry 4qzt coloured by chain, front view.
PDB entry 4qzt coloured by chain, side view.
PDB entry 4qzt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal.
Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, Vasileiou C, Borhan B, Geiger J
Acta Crystallogr D Biol Crystallogr 70 3226-32 (2014)
PMID: 25478840

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinol-binding protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 133 amino acids
Theoretical weight: 15.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50120 (Residues: 2-134; Coverage: 99%)
Gene names: CRBP2, RBP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand RTL 2 x RTL
Ligand ACT 3 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P1
Unit cell:
a: 36.406Å b: 54.179Å c: 68.444Å
α: 107.72° β: 97.19° γ: 103.59°
R-values:
R R work R free
0.183 0.18 0.244
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition.
Yabut et al. (2023)
6 other articles

6 mentions without citation

Retinol-binding protein 2 (RBP2): biology and pathobiology.
Blaner et al. (2020)
5 more