4r26

X-ray diffraction
2.5Å resolution

Crystal structure of human Fab PGT124, a broadly neutralizing and potent HIV-1 neutralizing antibody

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-143681 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin lambda constant 3 Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.06 KDa
Source organism: Nomascus leucogenys
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOY3 (Residues: 2-106; Coverage: 99%)
Gene name: IGLC3
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunoglobulin gamma-1 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 236 amino acids
Theoretical weight: 25.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 1-97, 107-108, 109-113, 115-223; Coverage: 47%)
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 62.686Å b: 40.331Å c: 84.457Å
α: 90° β: 91.67° γ: 90°
R-values:
R R work R free
0.235 0.233 0.267
Expression system: Homo sapiens