› 4r4n

X-ray diffraction
3.56Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211668 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope glycoprotein gp160 Chains: A, B, E, I, M, P, S, V
Molecule details ›
Chains: A, B, E, I, M, P, S, V
Length: 352 amino acids
Theoretical weight: 38.94 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ED04 (Residues: 43-485; Coverage: 41%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
M48U1 peptide Chains: a, b, e, i, m, p, s, v
Molecule details ›
Chains: a, b, e, i, m, p, s, v
Length: 28 amino acids
Theoretical weight: 3.06 KDa
Source organism: synthetic construct
Expression system: Not provided
Antibody 2.2c LIGHT CHAIN Chains: D, G, K, L, O, R, U, X
Molecule details ›
Chains: D, G, K, L, O, R, U, X
Length: 210 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Antibody 2.2c heavy CHAIN Chains: C, F, H, J, N, Q, T, W
Molecule details ›
Chains: C, F, H, J, N, Q, T, W
Length: 220 amino acids
Theoretical weight: 23.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 19 x NAG
3 modified residues:
Ligand DPR 8 x DPR
Ligand U2X 8 x U2X
Ligand OAS 8 x OAS

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 112.967Å b: 144.178Å c: 158.351Å
α: 110.58° β: 92.3° γ: 99.19°
R-values:
R R work R free
0.298 0.296 0.328
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

15 review citations

HIV antibodies for treatment of HIV infection.
Margolis et al. (2017)
14 more

1 mention without citation

Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.
Acharya et al. (2014)