› 4r7a

X-ray diffraction
1.85Å resolution

Crystal Structure of RBBP4 bound to PHF6 peptide

Released:
DOI: 10.2210/pdb4r7a/pdb
PDB entry 4r7a coloured by chain, front view.
PDB entry 4r7a coloured by chain, side view.
PDB entry 4r7a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of plant homeodomain finger 6 (PHF6) recognition by the retinoblastoma binding protein 4 (RBBP4) component of the nucleosome remodeling and deacetylase (NuRD) complex.
Liu Z, Li F, Zhang B, Li S, Wu J, Shi Y
J Biol Chem 290 6630-8 (2015)
PMID: 25601084

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170748 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PHD finger protein 6 Chain: A
Molecule details ›
Chain: A
Length: 15 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8IWS0 (Residues: 157-171; Coverage: 4%)
Gene names: CENP-31, KIAA1823, PHF6
Histone-binding protein RBBP4 Chain: B
Molecule details ›
Chain: B
Length: 425 amino acids
Theoretical weight: 47.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q09028 (Residues: 1-425; Coverage: 100%)
Gene names: RBAP48, RBBP4
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 50.63Å b: 87.55Å c: 95.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.207
Expression systems:
  • Not provided
  • Spodoptera frugiperda

Quick links

Citations

9 review citations

The genetics and mechanisms of T cell acute lymphoblastic leukaemia.
Belver et al. (2016)
8 more

3 mentions without citation

Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.
Moody et al. (2018)
2 more