› 4rfq

X-ray diffraction
2.4Å resolution

Human Methyltransferase-Like 18

Released:
DOI: 10.2210/pdb4rfq/pdb
PDB entry 4rfq coloured by chain, front view.
PDB entry 4rfq coloured by chain, side view.
PDB entry 4rfq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tempel W, Ravichandran M, Li Y, Walker JR, Bountra C, Arrowsmith CH, Edwards AM, Brown PJ, Hong BS, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N(tau)-methyl-L-histidine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131950 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histidine protein methyltransferase 1 homolog Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95568 (Residues: 63-372; Coverage: 78%)
Gene names: ASTP2, C1orf156, METTL18
Sequence domains: Methyltransferase domain

Ligands and Environments


Cofactor: Ligand SAM 1 x SAM
1 bound ligand:
Ligand UNX 12 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41212
Unit cell:
a: 70.15Å b: 70.15Å c: 170.688Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links