› 4rg7

X-ray diffraction
4.25Å resolution

Crystal structure of APC3

Released:
DOI: 10.2210/pdb4rg7/pdb
PDB entry 4rg7 coloured by chain, front view.
PDB entry 4rg7 coloured by chain, side view.
PDB entry 4rg7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.
Yamaguchi M, Yu S, Qiao R, Weissmann F, Miller DJ, VanderLinden R, Brown NG, Frye JJ, Peters JM, Schulman BA
J Mol Biol 427 1748-64 (2015)
PMID: 25490258

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division cycle protein 27 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 560 amino acids
Theoretical weight: 63.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30260 (Residues: 1-824; Coverage: 68%)
Gene names: ANAPC3, CDC27, D0S1430E, D17S978E
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P65
Unit cell:
a: 118.408Å b: 118.408Å c: 273.739Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.256 0.255 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
Alfieri et al. (2017)
7 more

1 mention without citation

Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.
Yamaguchi et al. (2015)