› 4rly

X-ray diffraction
2.5Å resolution

Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain

Released:
DOI: 10.2210/pdb4rly/pdb
PDB entry 4rly coloured by chain, front view.
PDB entry 4rly coloured by chain, side view.
PDB entry 4rly coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of diverse membrane target recognitions by ankyrins.
Wang C, Wei Z, Chen K, Ye F, Yu C, Bennett V, Zhang M
Elife 3 (2014)
PMID: 25383926

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-169569 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ankyrin-2; Sodium channel protein type 2 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 34.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99250 (Residues: 1102-1120; Coverage: 1%)
  • Canonical: Q01484 (Residues: 28-318; Coverage: 7%)
Gene names: ANK2, ANKB, HBA, NAC2, SCN2A, SCN2A1, SCN2A2
Sequence domains: Ankyrin repeat
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P4222
Unit cell:
a: 102.295Å b: 102.295Å c: 106.008Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.238
Expression system: Escherichia coli BL21(DE3)

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Citations

7 review citations

The Axon Initial Segment: An Updated Viewpoint.
Leterrier C. (2018)
6 more

3 mentions without citation

Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
Tewary et al. (2019)
2 more