› 4rma

X-ray diffraction
1.75Å resolution

Crystal structure of the FERM domain of human ezrin

Released:
DOI: 10.2210/pdb4rma/pdb
PDB entry 4rma coloured by chain, front view.
PDB entry 4rma coloured by chain, side view.
PDB entry 4rma coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.
Phang JM, Harrop SJ, Duff AP, Sokolova AV, Crossett B, Walsh JC, Beckham SA, Nguyen CD, Davies RB, Glöckner C, Bromley EH, Wilk KE, Curmi PM
Biochem J 473 2763-82 (2016)
PMID: 27364155

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ezrin Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 34.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15311 (Residues: 1-296; Coverage: 51%)
Gene names: EZR, VIL2
Sequence domains:
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 48.334Å b: 110.579Å c: 66.124Å
α: 90° β: 101.57° γ: 90°
R-values:
R R work R free
0.208 0.206 0.246
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

A biophysical perspective of the regulatory mechanisms of ezrin/radixin/moesin proteins.
Senju et al. (2022)
1 more

3 mentions without citation

Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition.
Michie et al. (2019)
2 more