› 4rox

X-ray diffraction
1.89Å resolution

Crystal Structure of P Domain of Hawaii Norovirus (GII.1)

Released:
DOI: 10.2210/pdb4rox/pdb
PDB entry 4rox coloured by chain, front view.
PDB entry 4rox coloured by chain, side view.
PDB entry 4rox coloured by chain, top view.
Source organism: Norovirus Hu/GII.1/7EK/Hawaii/1971/USA
Primary publication:
Structural Constraints on Human Norovirus Binding to Histo-Blood Group Antigens.
Singh BK, Leuthold MM, Hansman GS
mSphere 1
PMID: 27303720

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125449 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein VP1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 305 amino acids
Theoretical weight: 33.65 KDa
Source organism: Norovirus Hu/GII.1/7EK/Hawaii/1971/USA
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: J9XXB7 (Residues: 225-525; Coverage: 56%)
Gene name: VP1
Sequence domains: Calicivirus coat protein C-terminal
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EDO 7 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 139.06Å b: 78.16Å c: 74.66Å
α: 90° β: 122.42° γ: 90°
R-values:
R R work R free
0.178 0.177 0.201
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides.
Schroten et al. (2016)
2 more

4 mentions without citation

Structural Basis for Human Norovirus Capsid Binding to Bile Acids.
Kilic et al. (2019)
3 more